Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. I. Fermentation, isolation and biological activities.

Abstract

Urukthapelstatin A, a novel cyclic peptide, was isolated from the cultured mycelia of marine-derived Thermoactinomycetaceae bacterium Mechercharimyces asporophorigenens YM11-542. The peptide was purified by solvent extraction, silica gel chromatography, ODS flash chromatography, and finally by preparative HPLC. Urukthapelstatin A dose-dependently inhibited the growth of human lung cancer A549 cells with an IC(50) value of 12 nM. Urukthapelstatin A also showed potent cytotoxic activity against a human cancer cell line panel.

• Authors: Yoshihide Matsuo, Kaneo Kanoh, Takao Yamori, Hiroaki Kasai, Atsuko Katsuta, Kyoko Adachi, Kazuo Shin-Ya, Yoshikazu Shizuri
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 60 Issue 4 Pg. 251-5 (Apr 2007) ISSN: 0021-8820 [Print] England
• PMID: 17456975 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Thiazoles
• urukthapelstatin A
• Leucine

Topics

• Antibiotics, Antineoplastic (biosynthesis, isolation & purification, pharmacology)
• Cell Line, Tumor
• Fermentation
• Gram-Positive Endospore-Forming Bacteria (metabolism)
• Humans
• Leucine (analogs & derivatives, biosynthesis, isolation & purification, pharmacology)
• Thiazoles (isolation & purification, pharmacology)
• Water Microbiology