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[The significance of anti-soluble liver antigen/liver-pancreas in diagnosing and typing autoimmune hepatitis].

AbstractOBJECTIVE:
To study the significance of anti-soluble liver antigen/liver-pancreas (anti-SLA/LP) in diagnosing and typing autoimmune hepatitis (AIH).
METHODS:
Six thousand patients with abnormal liver functions, who had their autoantibodies checked by immunofluorescent assay (IFA) and immune blotting assay, were reviewed retrospectively.
RESULTS:
Of these 6000 patients with liver diseases, 84 were diagnosed AIH. Eighteen patients, 0.3% of the 6000, patients with abnormal liver functions, were SLA/LP antibody positive, of which 17 were with AIH-III [2/17 with AIH /primary biliary cirrhosis (PBC) overlap syndrome], and 1 with chronic hepatitis B. Sensitivity and specificity of SLA/LP antibody in diagnosing AIH were 20.2% and 99.7% respectively, and the positive prediction value was 94.44%. The antinuclear antibody (ANA) titer in the AIH-III group was significantly lower than that of the AIH-I group (P < 0.05). The age of patients with anti-SLA/LP was higher (58.8% were over 50 years old) than those without this antibody (52.2% were 30 to 50 years old). There were no significant differences between the type III and type I AIH regarding gender, age, abnormal degree of liver function, PTA, IgG, liver cirrhosis rates and response to immunosuppressive therapy.
CONCLUSION:
Anti-SLA/LP is highly specific for diagnosing AIH. Comparing the clinical data of type III and type I AIH, we did not find significant differences between the two groups.
AuthorsYan Zhao, Hui-ping Yan, Yu-fen Tan, Xia Feng, Yan Liu, Dan Cui, Dong-mei Ma, Wei-hua Li, Hai-ping Zhang
JournalZhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (Zhonghua Gan Zang Bing Za Zhi) Vol. 15 Issue 4 Pg. 283-6 (Apr 2007) ISSN: 1007-3418 [Print] China
PMID17456317 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Autoantibodies
  • Autoantigens
  • Immunoglobulin G
  • liver antigen LA-1
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Autoantibodies (immunology)
  • Autoantigens (immunology)
  • Child
  • Child, Preschool
  • Female
  • Hepatitis, Autoimmune (diagnosis, immunology)
  • Humans
  • Immunoglobulin G (immunology)
  • Immunophenotyping
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Retrospective Studies
  • Sensitivity and Specificity
  • Young Adult

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