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Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome.

AbstractOBJECTIVE:
To investigate the efficacy of a combined oral contraceptive containing 30 microg ethinyloestradiol and 3 mg drospirenone in the treatment of hyperandrogenism affecting women with the polycystic ovary syndrome (PCOS).
METHODS:
Prospective open study of 20 women for six cycles. At the beginning and at the end of the study the following values were determined: the Ferriman-Gallwey (F-G) score, body mass index, waist/hip ratio, serum levels of testosterone, SHBG, immune reactive insulin (IRI), glucose, the free androgenic index, and insulin resistance (HOMA-IR).
RESULTS:
All 20 women completed six cycles of therapy. The medication was well tolerated. At the end of the study there was a significant improvement of hirsutism, expressed in the decrease of the F-G score, accompanied by a decrease of testosterone and an increase of SHBG values. The carbohydrate metabolism was not affected significantly.
CONCLUSION:
The combined oral contraceptive containing 30 microg ethinyloestradiol and 3 mg drospirenone is an effective drug in the treatment of hyperandrogenism in women with PCOS; it elicits few side effects and does not significantly influence insulin resistance.
AuthorsB Pehlivanov, M Mitkov
JournalThe European journal of contraception & reproductive health care : the official journal of the European Society of Contraception (Eur J Contracept Reprod Health Care) Vol. 12 Issue 1 Pg. 30-5 (Mar 2007) ISSN: 1362-5187 [Print] England
PMID17455042 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Androstenes
  • Blood Glucose
  • Contraceptives, Oral, Combined
  • Insulin
  • Sex Hormone-Binding Globulin
  • Testosterone
  • Ethinyl Estradiol
  • drospirenone
Topics
  • Adult
  • Androstenes (administration & dosage)
  • Blood Glucose
  • Body Mass Index
  • Contraceptives, Oral, Combined (administration & dosage)
  • Ethinyl Estradiol (administration & dosage)
  • Female
  • Humans
  • Insulin (blood)
  • Polycystic Ovary Syndrome (blood, drug therapy, pathology)
  • Prospective Studies
  • Severity of Illness Index
  • Sex Hormone-Binding Globulin (metabolism)
  • Testosterone (blood)
  • Treatment Outcome

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