Abstract | BACKGROUND/AIMS: METHODS: This multicentric prospective study included 129 patients: patients with progressive sensorineural HL or with Menière's disease, together with their control group corresponding to patients with similar symptoms, but of presumably known origin. Detection of antibodies to myelin P0 protein was performed by using western blots. NORMAL: The prevalence of antibodies to myelin P0 protein in patients with rapidly progressive HL was not statistically different from that of the control group corresponding to genetic HL patients (30 versus 28%). In patients with Menière's disease, the prevalence was lower than that of the control group corresponding to patients with benign paroxysmal positional vertigo (5.4 versus 18.7%). No patient with auto- immune disease had antibodies to myelin P0 protein. CONCLUSIONS:
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Authors | Bach-Nga Pham, Milan Rudic, Didier Bouccara, Olivier Sterkers, Nadia Belmatoug, Jean-Pierre Bébéar, Vincent Couloigner, Bernard Fraysse, André Gentine, Eugène Ionescu, Alain Robier, Jean-Pierre Sauvage, Eric Truy, Thierry Van Den Abbeele, Evelyne Ferrary |
Journal | Autoimmunity
(Autoimmunity)
Vol. 40
Issue 3
Pg. 202-7
(May 2007)
ISSN: 0891-6934 [Print] England |
PMID | 17453719
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Biomarkers
- Myelin P0 Protein
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Autoantibodies
(biosynthesis, blood)
- Autoimmune Diseases of the Nervous System
(blood, immunology)
- Biomarkers
(blood)
- Child
- Child, Preschool
- Ear Diseases
(blood, immunology)
- Ear, Inner
(immunology)
- Female
- Humans
- Male
- Middle Aged
- Myelin P0 Protein
(immunology)
- Prospective Studies
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