Abstract | OBJECTIVE: Despite numerous clinical trials, it is unknown whether ethnicity affects treatment response to cognitive enhancers in Alzheimer's disease (AD). There is convincing evidence of ethnic and genetic variability in drug metabolism. This article reviews the available data on ethnicity in clinical trials for AD to answer two questions: (1) what are the challenges to diagnose and treat AD across different ethnic groups, and (2) are there differences in response to pharmacologic interventions for AD across these different ethnic groups? METHOD: RESULTS: The participation of ethnic minority subjects in clinical trials for AD was dependent on the funding source, although Caucasian participants were over-represented and non-Caucasian participants were under-represented in the clinical trials. Because of the low participation rate of ethnic minorities, there were insufficient data to assess any differences in treatment outcome among different ethnic groups. Strategies to improve diversity in clinical trials are discussed. CONCLUSION: Greater participation of ethnically diverse participants in clinical trials for AD would generate additional information on possible differences in metabolism, treatment response, adverse events to therapeutic agents, and could foster the investigation of genetic variability among ethnic groups.
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Authors | Warachal E Faison, Susan K Schultz, Jeroen Aerssens, Jennifer Alvidrez, Ravi Anand, Lindsay A Farrer, Lissy Jarvik, Jennifer Manly, Thomas McRae, Greer M Murphy Jr, Jason T Olin, Darrel Regier, Mary Sano, Jacobo E Mintzer |
Journal | International psychogeriatrics
(Int Psychogeriatr)
Vol. 19
Issue 3
Pg. 539-58
(Jun 2007)
ISSN: 1041-6102 [Print] England |
PMID | 17451614
(Publication Type: Journal Article, Review)
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Chemical References |
- Indans
- Nootropic Agents
- Phenylcarbamates
- Piperidines
- Thiazoles
- Galantamine
- Donepezil
- sabeluzole
- Rivastigmine
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Topics |
- Aged
- Alzheimer Disease
(diagnosis, drug therapy, ethnology)
- Cross-Cultural Comparison
- Donepezil
- Ethnicity
(psychology, statistics & numerical data)
- Galantamine
(therapeutic use)
- Humans
- Indans
(therapeutic use)
- Nootropic Agents
(therapeutic use)
- Phenylcarbamates
(therapeutic use)
- Piperidines
(therapeutic use)
- Randomized Controlled Trials as Topic
(statistics & numerical data)
- Rivastigmine
- Thiazoles
(therapeutic use)
- White People
(psychology, statistics & numerical data)
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