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Displacement of dermal solar elastosis in malignant melanoma.

AbstractBACKGROUND:
Ultraviolet radiation (UVR) is a major environmental causal factor for skin malignancy. In this study, we investigated the morphology of the solar elastosis (SE) band in benign and malignant melanocytic lesions.
METHODS:
We measured the SE band in perilesional and lesional skin of 13 melanomas (9 invasive and 4 in situ) and 11 melanocytic nevi (5 usual intradermal nevi, 4 blue nevi and 2 desmoplastic nevi) occurring in sun-exposed areas.
RESULTS:
The melanoma and nevus groups had similar age range, gender ratio and anatomic distribution. The mean SE thickness was 0.35 mm in melanomas and 0.29 mm in nevi (p = 0.56), indicating similar UVR exposure. There was a mean downward SE displacement (SED) of 0.43 mm in melanomas and essentially no displacement (-0.02 mm) in nevi (p < 0.005). Tumor cells and inflammatory host response were responsible for SED in melanoma.
CONCLUSIONS:
SED may help in the differential diagnosis of melanocytic lesions in sun-exposed areas. In melanoma, the new lesion depresses the pre-existing SE band. Conversely, the long-standing nevus co-exists with the SE band without significant displacement. Evaluation of the SE band may help to differentiate melanoma with chronic sun-induced damage as they have a distinct set of molecular alterations.
AuthorsMarcelo G Horenstein, Courtney L Norton, Tara N Evans
JournalJournal of cutaneous pathology (J Cutan Pathol) Vol. 34 Issue 5 Pg. 376-80 (May 2007) ISSN: 0303-6987 [Print] United States
PMID17448191 (Publication Type: Journal Article)
Topics
  • Aged
  • Aged, 80 and over
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Melanoma (complications, pathology)
  • Middle Aged
  • Nevus, Pigmented (pathology)
  • Skin Diseases (complications, pathology)
  • Skin Neoplasms (complications, pathology)
  • Sunlight (adverse effects)

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