Abstract | BACKGROUND: Evaluation of conditions associated with glycated hemoglobin (HbA1c) values below the reference range in HbA1c determinations. METHODS: Over a time period of 5 years, HbA1c results were determined with the ion-exchange high-performance liquid chromatography (HPLC) method HA-8140 Menarini. RESULTS: CONCLUSIONS: In patients with liver cirrhosis, HbA1c measurements should be used with caution when evaluating long-term glucose control, and samples with suspected Hb variants should be analyzed by hemoglobin electrophoresis. Our study underscores the need for clinical laboratories and physicians to be aware of the limitations of their HbA1c assay methods as well as of the importance of visual inspection of ion-exchange chromatograms to detect HbA1c values below the reference range and abnormalities caused by the interference factors described here.
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Authors | Wolfgang J Schnedl, Theresa Lahousen, Robert Krause, Sandra J Wallner, Claudia Piswanger-Soelkner, Rainer W Lipp |
Journal | Clinical laboratory
(Clin Lab)
Vol. 53
Issue 3-4
Pg. 179-81
( 2007)
ISSN: 1433-6510 [Print] Germany |
PMID | 17447655
(Publication Type: Journal Article)
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Chemical References |
- Glycated Hemoglobin A
- Hemoglobins, Abnormal
- Fetal Hemoglobin
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Topics |
- Anemia
(blood, complications)
- Chromatography, High Pressure Liquid
(methods, standards)
- Chromatography, Ion Exchange
(methods, standards)
- Fetal Hemoglobin
(analysis)
- Glycated Hemoglobin
(analysis)
- Hematologic Neoplasms
(complications, pathology)
- Hemoglobins, Abnormal
(analysis)
- Humans
- Liver Cirrhosis
(blood, pathology)
- Reference Values
- Retrospective Studies
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