Abstract | BACKGROUND/AIMS: PATIENTS AND METHODS: Between January 1996 and January 1998, 69 patients with pathologically confirmed CRC who received routine follow-up at the Ruijin Hospital were included in this study. VEGF-C and VEGF-D protein expression and microvessel density of 69 surgical specimens were assessed by immunohistochemistry, with 20 samples of normal colorectal tissues as controls. All patients were followed up for 108 months or until death. The Immunohistochemical stains were quantified and analyzed by means of a Zeiss Axioplan 2 imaging analysis system. RESULTS: The protein expression of VEGF-C and VEGF-D in tumor tissues was much higher than that in normal colorectal tissues (p < 0.01). The VEGF-C expression significantly correlated with lymph node metastasis (p = 0.011) and clinical stages of CRC (p < 0.01). The VEGF-D expression correlated with patient ages (p = 0.013), depth of tumor invasion (p = 0.013), and lymph node metastasis (p = 0.028). The expression of VEGF-C and VEGF-D was significantly correlated with the microvessel density. Both overall survival and disease-free survival at 108 months were significantly lower in the CRC patients with a high VEGF-C and/or a high VEGF-D expression, and the patients with a high expression of both VEGF-C and VEGF-D had the shortest overall survival and disease-free survival when compared with other patients. CONCLUSION:
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Authors | W-G Hu, J-W Li, B Feng, M Beveridge, F Yue, A-G Lu, J-J Ma, M-L Wang, Y Guo, X-L Jin, M-H Zheng |
Journal | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
(Eur Surg Res)
Vol. 39
Issue 4
Pg. 229-38
( 2007)
ISSN: 1421-9921 [Electronic] Switzerland |
PMID | 17446709
(Publication Type: Journal Article)
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Copyright | Copyright 2007 S. Karger AG, Basel. |
Chemical References |
- Biomarkers, Tumor
- VEGFC protein, human
- Vascular Endothelial Growth Factor C
- Vascular Endothelial Growth Factor D
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Topics |
- Adenocarcinoma
(blood supply, metabolism, mortality, pathology)
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Colorectal Neoplasms
(blood supply, metabolism, mortality, pathology)
- Disease-Free Survival
- Female
- Follow-Up Studies
- Humans
- Immunohistochemistry
(methods)
- Lymphatic Metastasis
- Male
- Microcirculation
- Microscopy
(instrumentation, methods)
- Middle Aged
- Neovascularization, Pathologic
(metabolism, mortality, pathology)
- Prognosis
- Survival Analysis
- Vascular Endothelial Growth Factor C
(metabolism)
- Vascular Endothelial Growth Factor D
(metabolism)
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