HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Evolution of antibody response and fungal antigens in the serum of a patient infected with Candida famata.

Abstract
The presence of fungal antibodies and antigens in the serum of a patient diagnosed in 1996 with acute zonal occult outer retinopathy caused by Candida famata infection was examined. Antibodies against C. famata increased until 1999-2000 when antifungal treatment was initiated. The antibodies were detected by ELISA and immunofluorescence analysis using C. famata. These antibodies were not immunoreactive against several Candida species tested. Positive immunofluorescence was obtained with IgM, but not IgA, IgG or IgE. Moreover, the IgM response disappeared several months after treatment with antifungal compounds, despite the fact that C. famata antigens were present in the blood. Finally, a sensitive test was developed to assay for the presence of C. famata antigens in serum based on the immunodetection of fungal antigens transferred to a nitrocellulose membrane and incubated with rabbit antibodies raised against C. famata. According to this method, the infection diminished with antifungal treatment.
AuthorsDiana Pisa, Marta Ramos, Susana Molina, Patricia García, Luis Carrasco
JournalJournal of medical microbiology (J Med Microbiol) Vol. 56 Issue Pt 5 Pg. 571-578 (May 2007) ISSN: 0022-2615 [Print] England
PMID17446276 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Fungal
  • Antifungal Agents
  • Antigens, Fungal
  • Immunoglobulin M
Topics
  • Antibodies, Fungal (blood)
  • Antifungal Agents (therapeutic use)
  • Antigens, Fungal (blood)
  • Candida (immunology)
  • Candidiasis (drug therapy, immunology, microbiology)
  • Enzyme-Linked Immunosorbent Assay
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • Immunoblotting
  • Immunoglobulin M (blood)
  • Microscopy, Immunoelectron
  • Middle Aged
  • Retinal Diseases (immunology, microbiology)
  • Serum (immunology, microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: