HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hyperalgesia in response to traumatic occlusion and GFAP expression in rat parabrachial [correction of parabranchial] nucleus: modulation with fluorocitrate.

Abstract
We have examined, by immunocytochemical methods and nociceptive behavior assessment in rats, whether astrocytes in the parabrachial nucleus (PBN) are involved in the regulation of traumatic occlusion. The expression of glial fibrillary acidic protein (GFAP) in PBN of ipsilateral and contralateral sides was up-regulated 4 h after occlusal changes in molars, reached peak levels at 24 h, and was then gradually down-regulated. PBN astrocytes activated by traumatic occlusion were found to have enlarged cell bodies and thickened processes within 8 h. An inhibitor of glia metabolism (FCA, fluorocitrate) reduced astrocyte activation and significantly attenuated the development of pain hypersensitivity in this model. The results suggested that the GFAP-immunoreactive astrocytes in PBN within the bridge of Varolius were activated by traumatic occlusion, and that they were involved in the transmission and modulation of nociceptive information in the central nervous system. However, although astrocytes in PBN are thus probably involved in causing post-occlusal hyperalgesia, we have not been able to exclude that astrocytes at other locations also contribute to this effect.
AuthorsJinwu Chen, Jun Zhang, Yimin Zhao, Lintian Yuan, Xin Nie, Jianfu Li, Zhiwei Ma, Yongjie Zhang, Qi Wang, Yongjin Chen, Yan Jin, Zhiren Rao
JournalCell and tissue research (Cell Tissue Res) Vol. 329 Issue 2 Pg. 231-7 (Aug 2007) ISSN: 0302-766X [Print] Germany
PMID17443351 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Citrates
  • Glial Fibrillary Acidic Protein
  • fluorocitrate
Topics
  • Animals
  • Astrocytes (drug effects, metabolism)
  • Citrates (pharmacology)
  • Dental Occlusion, Traumatic (complications, metabolism)
  • Fluorescent Antibody Technique
  • Glial Fibrillary Acidic Protein (biosynthesis)
  • Hyperalgesia (etiology, metabolism)
  • Male
  • Physical Stimulation
  • Rats
  • Rats, Sprague-Dawley
  • Ventral Tegmental Area (drug effects, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: