Abstract | OBJECTIVE: METHODS: Polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) analysis was used to study the variant allele frequency distributions of COMT Val158Met genetic polymorphism in a population based case-control study with 132 endometrial cancer cases and 110 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression after adjustment for known or suspected risk factors for endometrial cancer. RESULTS: The most frequent genotype was COMT( Val/Val) (47.2%, 52/110) in control group and COMT(Val/Met) (58.3%, 77/132) in endometrial cancer group. The difference between the two groups was of statistical significance (P < 0.05). Compared with COMT( Met/Met) genotype, the COMT( Val/Val) genotype was inversely correlated with endometrial cancer risk, and the adjusted OR value was 0.262 (95% CI: 0.080 - 0.862, P = 0.027). CONCLUSIONS: Among the genotypes in women in South China, genotype COMT( Val/Val) is mostly seen, followed by COMT(Val/Met), and COMT( Met/Met) is the least in control group. The endometrial cancer susceptivity of genotype COMT( Val/Val) carriers may be lower than COMT( Met/Met) carriers.
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Authors | Xiao-Miao Zhao, Mei-Qing Xie, Dong-Zi Yang, Liang-An Wang, Shi-Jie Li, Yan-Yan Zhuang, Xue-Lian Tang |
Journal | Zhonghua fu chan ke za zhi
(Zhonghua Fu Chan Ke Za Zhi)
Vol. 42
Issue 2
Pg. 116-9
(Feb 2007)
ISSN: 0529-567X [Print] China |
PMID | 17442187
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Catechol O-Methyltransferase
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Topics |
- Adult
- Catechol O-Methyltransferase
(genetics)
- Endometrial Neoplasms
(enzymology, genetics)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Menopause
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Regression Analysis
- Risk Factors
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