| Abstract | OBJECTIVE: To evaluate the effects of insulin in multiple daily injections (MDI) on peripheral glucose disposal in Latin American patients with type 2 diabetes. METHODS AND RESULTS: Ten Latin American patients (four men and six women) with type 2 diabetes between the ages of 32 and 45 years were evaluated. All women were premenopausal and had regular menstrual periods. A hyperinsulinemic-euglycemic clamp procedure was performed at baseline and was repeated approximately 2 years after insulin monotherapy on MDI was initiated. Both genders had comparable baseline anthropometric and laboratory features, including a mean body mass index > 30 kg/m2 and percent body fat > 30%. Baseline percent hemoglobin A1c (HbA1c%) was 9.5 +/- 1.5%, and post-intervention HbA1c% was 7.0 +/- 1.2%. The peripheral glucose disposal rate at baseline was 4.5 +/- 2.2 mg/kg/min fat-free mass and at postintervention was 3.6 +/- 2.3 mg/kg/min fat-free mass. CONCLUSIONS: Despite a significant improvement in glycemic control, MDI did not seem to increase the insulin-mediated glucose disposal rate. Underlying obesity and increased percent body fat may have been the most counteracting factors on the potential improvement in insulin sensitivity expected with insulin monotherapy. |
| Authors | Larissa Avilés-Santa, Karin Salinas, Beverley Adams-Huet, Philip Raskin
(Affiliation: Department of Medicine, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd G5.238, Dallas, TX 75390-8858, USA. Maines.Aviles-Santa at UTSouthwestern.edu)
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| Journal | Journal of investigative medicine : the official publication of the American Federation for Clinical Research
(J Investig Med)
Vol. 55
Issue 1
Pg. 11-7
(Jan 2007)
ISSN: 1081-5589 Canada |
| PMID | 17441407
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)
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| Chemical References |
- Blood Glucose
- Hemoglobin A, Glycosylated
- Hemoglobins
- Hypoglycemic Agents
- hemoglobin A1c protein, human
- Insulin
|
| Topics |
- Adiposity
(drug effects, ethnology)
- Adult
- Blood Glucose
(metabolism)
- Body Mass Index
- Diabetes Mellitus, Type 2
(blood, complications, drug therapy)
- Drug Administration Schedule
- Female
- Glucose Clamp Technique
- Hemoglobin A, Glycosylated
- Hemoglobins
(analysis, drug effects)
- Humans
- Hypoglycemic Agents
(administration & dosage)
- Injections
- Insulin
(administration & dosage)
- Insulin Resistance
(ethnology)
- Latin America
(ethnology)
- Male
- Middle Aged
- Obesity
(blood, complications, ethnology)
- Texas
(epidemiology)
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