HLA antigens in donovanosis (granuloma inguinale).

Abstract

OBJECTIVE:

To compare the frequencies of HLA antigens in patients with donovanosis and in controls.

DESIGN:

HLA Class I, Class II and DQ antigens were detected in patients with genital ulceration caused by donovanosis and in a control group.

SETTING:

City Health STD Clinic, King Edward VIII Hospital, Durban, South Africa. Participants--Sixty (47 men, 13 women) patients with donovanosis.

RESULTS:

HLA B57 was detected in nine of 60 (15%) with donovanosis and 75 of 1478 (5.1%) controls (RR = 3.3 chi 2 = 11.0, p = 0.001, p corrected = 0.026).

CONCLUSIONS:

A possible link between donovanosis and HLA B57 could be explained by coexisting alleles or immune response genes in linkage disequilibrium altering disease susceptibility.

• Authors: N O'Farrell, M Hammond
• Journal: Genitourinary medicine (Genitourin Med) Vol. 67 Issue 5 Pg. 400-2 (Oct 1991) ISSN: 0266-4348 [Print] England
• PMID: 1743713 (Publication Type: Comparative Study, Journal Article)

Chemical References

• HLA Antigens
• HLA-B Antigens

Topics

• Disease Susceptibility
• Female
• Granuloma Inguinale (immunology)
• HLA Antigens (analysis)
• HLA-B Antigens (analysis)
• Histocompatibility Testing
• Humans
• Male
• Risk Factors
• South Africa