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Long-term follow-up of polypoidal choroidal vasculopathy after photodynamic therapy with verteporfin.

AbstractPURPOSE:
To report on the clinical features of three cases of polypoidal choroidal vasculopathy (PCV) during long-term follow-up after photodynamic therapy (PDT).
DESIGN:
Interventional case reports.
METHODS:
Among the participants in the Japanese Age-Related Macular Degeneration Trial (JAT) at our hospital, a PCV was seen in three eyes at baseline on retrospective analysis of indocyanine green angiography (ICGA) using fundus camera. We report the clinical features of these cases during more than 4 years follow-up.
RESULTS:
The mean number of PDT treatments was 5.7. Improved visual acuity (VA) and cessation of fluorescein leakage was achieved within 18 months in all eyes; however, subretinal hemorrhage and subfoveal fluid recurred due to new or recurrent PCV. The final VA decreased markedly in two eyes.
CONCLUSIONS:
The eyes with PCV, which had been treated successfully with PDT, may have developed new or recurrent PCV during long-term follow-up. Periodical ICGA would be needed to detect abnormal choroidal vascular changes.
AuthorsKaori Sayanagi, Fumi Gomi, Miki Sawa, Masahito Ohji, Yasuo Tano
JournalGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 245 Issue 10 Pg. 1569-71 (Oct 2007) ISSN: 0721-832X [Print] Germany
PMID17437122 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Coloring Agents
  • Photosensitizing Agents
  • Porphyrins
  • Verteporfin
  • Indocyanine Green
Topics
  • Aged
  • Choroid (blood supply)
  • Coloring Agents
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Humans
  • Indocyanine Green
  • Male
  • Peripheral Vascular Diseases (diagnosis, drug therapy)
  • Photochemotherapy
  • Photosensitizing Agents (therapeutic use)
  • Porphyrins (therapeutic use)
  • Retrospective Studies
  • Verteporfin
  • Visual Acuity

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