Primary solitary eosinophilic granuloma of the brain and postoperative radiotherapy: a clinical case.

Abstract

A case of solitary eosinophilic granuloma (EG) of the brain in a 53-year-old woman is presented. The tumor developed in the anterior cranial fossa causing destruction of the skull basis and the retrobulbar space, accompanied by vision impairment. The tumor was partially excised and the patient was irradiated postoperatively with 40 Gy 6 MV x-rays, followed by 10 cycles of chemotherapy. Follow-up computed tomography (CT) showed no response at 30 Gy and no progression during chemotherapy. Attention is drawn to cases of EG indolent in growth but resistant to radiation and chemotherapy.

• Authors: L Mihova, M Yaneva, M Sopadjieva, V Andreev, I Nejtcheva
• Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology (J BUON) 2007 Jan-Mar Vol. 12 Issue 1 Pg. 125-8 ISSN: 1107-0625 [Print] Cyprus
• PMID: 17436414 (Publication Type: Case Reports, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Brain Neoplasms (complications, drug therapy, pathology, radiotherapy, surgery)
• Chemotherapy, Adjuvant
• Disease Progression
• Eosinophilic Granuloma (complications, drug therapy, pathology, radiotherapy, surgery)
• Female
• Humans
• Middle Aged
• Radiotherapy, Adjuvant
• Skull Base (pathology)
• Tomography, X-Ray Computed
• Treatment Failure
• Vision Disorders (etiology, radiotherapy)