| Abstract | Cutaneous verrucous carcinoma is a low-grade and well-differentiated variant of squamous cell carcinoma. This rare neoplasm follows a seemingly indolent progression and exhibits a low metastatic potential. Photodynamic therapy relies on the selective intratumoral cell accumulation and photoactivation of a photosensitizer, leading to the generation of phototoxic compounds responsible for necrosis and apoptosis of the target cells. An 82-year-old man presenting with a large long-standing verrucous carcinoma on the leg was treated successfully by 6 photodynamic therapy sessions administered at weekly intervals using methyl-aminolevulinate and 57-J/cm(2) irradiations at 634-nm wavelength. The use of methyl-aminolevulinate-photodynamic therapy for treating cutaneous verrucous carcinoma had not been reported so far. It may represent a convenient therapeutic alternative in this setting. |
| Authors | Arjen F Nikkels, Laurence Thirion, Pascale Quatresooz, Gérald E Piérard
(Affiliation: Department of Dermatopathology, University Hospital of Liège, Belgium. af.nikkels at chu.ulg.ac.be)
|
| Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 57
Issue 3
Pg. 516-9
(Sep 2007)
ISSN: 1097-6787 United States |
| PMID | 17434646
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Photosensitizing Agents
- methyl 5-aminolevulinate
- Aminolevulinic Acid
|
| Topics |
- Aged, 80 and over
- Aminolevulinic Acid
(administration & dosage, analogs & derivatives, therapeutic use)
- Carcinoma, Verrucous
(drug therapy, pathology)
- Chronic Disease
- Drug Administration Schedule
- Humans
- Leg Dermatoses
(drug therapy, pathology)
- Male
- Photochemotherapy
- Photosensitizing Agents
(administration & dosage, therapeutic use)
- Skin Neoplasms
(drug therapy, pathology)
- Treatment Outcome
|
