Nucleolar organizer regions argyrophilic associated proteins in cutaneous melanocytic lesions.

Abstract

We applied a simple silver staining technique to visualize nucleolar organizer regions associated proteins (AgNORs) for the study of 47 melanocytic lesions (20 malignant melanomas, 5 dysplastic nevi, 4 Spitz nevi, 2 Reed and Gartman's fusiform nevi and 16 melanocytic nevi). A statistically significant difference existed between the numbers of AgNORs per cell in benign and malignant lesions as a group. However, some overlapping counts were found, limiting the usefulness of the technique in differentiating benign from malignant lesions in individual cases.

• Authors: J P Reis, O Tellechea, A P Baptista
• Journal: Dermatologica (Dermatologica) Vol. 183 Issue 2 Pg. 136-8 ( 1991) ISSN: 0011-9075 [Print] Switzerland
• PMID: 1743375 (Publication Type: Journal Article)

Chemical References

• Antigens, Nuclear
• Nuclear Proteins
• nucleolar organizer region associated proteins

Topics

• Antigens, Nuclear
• Diagnosis, Differential
• Evaluation Studies as Topic
• Humans
• Melanoma (diagnosis, epidemiology, pathology)
• Nevus (diagnosis, epidemiology, pathology)
• Nuclear Proteins (chemistry)
• Sensitivity and Specificity
• Silver Staining (methods, standards)
• Skin Neoplasms (diagnosis, epidemiology, pathology)