Laryngeal
amyloidosis can be secondary to an underlying lymphoid neoplastic process and in view of this concept; the cases of localized laryngeal
amyloidosis should be carefully examined and investigated for the presence of a lymphomatous process. The study design is case report. We report the case of a 64-year-old man with progressive
hoarseness. A biopsy showed histological findings consistent with an extramedullary
plasmacytoma associated with localized
amyloidosis involving the right hemilarynx (ventricular band, arytenoids and true cord). Immunohistochemical studies showed that the tumour cells of the
plasmacytoma were monoclonal (lambda-restricted). PCR analysis of the IgH gene demonstrated a clonal band confirming B-cell clonality. The
amyloid deposits were also shown to be reactive with
lambda immunoglobulin light chain, suggesting the pathogenetic relationship between the
plasmacytoma and
amyloid deposition in the larynx. There was no other evidence of
malignancy or
amyloidosis elsewhere. The majority of the cases reported of
amyloid deposition with
plasmacytoma, the lesions were found in the nasopharynx, in contrast to our case in which the lesions were sited in the larynx and with the peculiarity of being multiples. Moreover,
amyloid and
plasmacytoma were clearly delimitated and the
amyloid tissue was more extensive than the tumour tissue. This case supports the concept that localized laryngeal
amyloidosis may be a manifestation of low-grade B-cell
neoplasms.