Rare expression of BSAP (PAX-5) in mature T-cell lymphomas.

Abstract

Lineage determination in lymphomas is based on the assessment of lineage-specific markers, such as the B-cell-specific activator protein of the paired box family (BSAP, PAX-5) for the B-cell lineage. BSAP is thought to be expressed exclusively in B cells from the pro-B- to the mature B-cell stage and then silenced in plasma cells. BSAP has oncogenic potential and experimental evidence shows that the T-cell lineage is prone to this effect. Herein, we report on a BSAP-positive peripheral T-cell lymphoma with monoclonal T-cell receptor gamma-gene rearrangement. To assess the relative frequency of BSAP expression in mature T-cell lymphomas, we constructed and examined a tissue microarray consisting of 43 angioimmunoblastic T-cell lymphomas and peripheral T-cell lymphomas and detected no additional BSAP-positive cases. To conclude, BSAP can probably contribute to T-cell lymphomagenesis not only in vitro, but also in vivo. It is rarely expressed in peripheral T-cell lymphoma, thus its detection on lymphoid malignancies cannot be considered definitively lineage specific.

• Authors: Alexandar S Tzankov, Philip T Went, Simone Münst, Thomas Papadopoulos, Gernot Jundt, Stephan R Dirnhofer
• Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (Mod Pathol) Vol. 20 Issue 6 Pg. 632-7 (Jun 2007) ISSN: 0893-3952 [Print] United States
• PMID: 17431414 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• PAX5 Transcription Factor
• PAX5 protein, human

Topics

• Aged
• Biomarkers, Tumor (biosynthesis)
• Cell Lineage
• Female
• Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
• Humans
• Lymphoma, T-Cell (metabolism, pathology)
• Lymphoma, T-Cell, Peripheral (metabolism)
• Male
• Middle Aged
• PAX5 Transcription Factor (biosynthesis)
• Tissue Array Analysis