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[Successful low-dose TS-1 administration in an elderly colon cancer patient with liver metastasis].

Abstract
An 85-year-old man, who had undergone right hemicolectomy and partial hepatectomy for caecum cancer with liver metastasis, was diagnosed with recurrent multiple liver metastasis 10 months after surgery. TS-1 administration at a dose of 80 mg/day induced grade 3 anorexia, and after complete recovery from the adverse reaction, it was converted to a low-dose TS-1 administration at 40 mg/day. This treatment reduced the diameter of the liver metastasis and was continued for ten months without any adverse reaction. Pharmacokinetic analysis in this patient on low-dose TS-1 showed that Cmax and AUC of 5-chloro-2,4-dihydroxypyridine (CDHP) were equivalent to the values reported in cancer patients with normal renal function receiving standard-dose administration. TS-1 therapy may provide a safe and effective alternative to chemotherapy for elderly patients with advanced colorectal carcinoma. Pharmacokinetic analysis could be useful for determining the ideal dose of TS-1.
AuthorsTadashi Ohnishi, Toshiyuki Kanoh, Yutaka Kimura, Takashi Iwazawa, Takeshi Tono, Yoshiaki Nakano, Koji Yano, Takushi Monden
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 4 Pg. 623-5 (Apr 2007) ISSN: 0385-0684 [Print] Japan
PMID17431353 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antimetabolites, Antineoplastic
  • Drug Combinations
  • S 1 (combination)
  • Tegafur
  • Oxonic Acid
Topics
  • Adenocarcinoma (drug therapy, metabolism, secondary)
  • Aged, 80 and over
  • Antimetabolites, Antineoplastic (administration & dosage, pharmacokinetics)
  • Appendiceal Neoplasms (secondary, surgery)
  • Colonic Neoplasms (drug therapy, metabolism, pathology)
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Combinations
  • Humans
  • Liver Neoplasms (secondary, surgery)
  • Male
  • Oxonic Acid (administration & dosage, pharmacokinetics)
  • Tegafur (administration & dosage, pharmacokinetics)

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