[Successful low-dose TS-1 administration in an elderly colon cancer patient with liver metastasis].

Abstract

An 85-year-old man, who had undergone right hemicolectomy and partial hepatectomy for caecum cancer with liver metastasis, was diagnosed with recurrent multiple liver metastasis 10 months after surgery. TS-1 administration at a dose of 80 mg/day induced grade 3 anorexia, and after complete recovery from the adverse reaction, it was converted to a low-dose TS-1 administration at 40 mg/day. This treatment reduced the diameter of the liver metastasis and was continued for ten months without any adverse reaction. Pharmacokinetic analysis in this patient on low-dose TS-1 showed that Cmax and AUC of 5-chloro-2,4-dihydroxypyridine (CDHP) were equivalent to the values reported in cancer patients with normal renal function receiving standard-dose administration. TS-1 therapy may provide a safe and effective alternative to chemotherapy for elderly patients with advanced colorectal carcinoma. Pharmacokinetic analysis could be useful for determining the ideal dose of TS-1.

• Authors: Tadashi Ohnishi, Toshiyuki Kanoh, Yutaka Kimura, Takashi Iwazawa, Takeshi Tono, Yoshiaki Nakano, Koji Yano, Takushi Monden
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 4 Pg. 623-5 (Apr 2007) ISSN: 0385-0684 [Print] Japan
• PMID: 17431353 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid

Topics

• Adenocarcinoma (drug therapy, metabolism, secondary)
• Aged, 80 and over
• Antimetabolites, Antineoplastic (administration & dosage, pharmacokinetics)
• Appendiceal Neoplasms (secondary, surgery)
• Colonic Neoplasms (drug therapy, metabolism, pathology)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Combinations
• Humans
• Liver Neoplasms (secondary, surgery)
• Male
• Oxonic Acid (administration & dosage, pharmacokinetics)
• Tegafur (administration & dosage, pharmacokinetics)