Abstract |
Vinorelbine (VNB) is one of new semi-synthesized vinka alkaloids developed in France, of which anti- tumor activity is susceptible mainly to non-small cell lung cancer and breast cancer. Moreover, its clinical efficacy has been noted from single-agent therapy or combination therapy with taxanes. It is assumed that VNB selectively acts on tubulin which elaborates microtubules, strands the cells at G 1 phase and interferes with the mitosis. VNB has unique anti- tumor activity as an antimicrotubule agent and is expected to be available for treatment of multi- drug resistant tumors. In this report, we demonstrate that VNB, as an antimicrotubule agent, induces apoptosis in breast cancer cell line, MX-1 via a mitochondrial pathway.
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Authors | Hiroo Nakajima, Koichi Sakaguchi, Naruhiko Mizuta, Ikuya Fujiwara, Akemi Hayakawa, Junji Magae |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 34
Issue 4
Pg. 583-8
(Apr 2007)
ISSN: 0385-0684 [Print] Japan |
PMID | 17431345
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Vinblastine
- Caspases
- Vinorelbine
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Topics |
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Apoptosis
(drug effects, genetics)
- Breast Neoplasms
(pathology)
- Caspases
(metabolism)
- Cell Survival
(drug effects)
- Female
- Humans
- Mitochondria
(metabolism, physiology)
- Tumor Cells, Cultured
- Vinblastine
(analogs & derivatives, pharmacology)
- Vinorelbine
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