Abstract | BACKGROUND & OBJECTIVE: METHODS: The sensitivity of fresh human cervical cancer cells from 32 patients to 9 cytotoxic drugs was tested using in vitro MTT assay. RESULTS: The cytotoxic activities of the 9 drugs for cervical cancer were in sequence from high to low as follows: liposomal paclitaxel, taxol, carboplatin (CBP), ifosfamide (IFO), etoposide (VP-16), 5-fluorouracil (5-FU), cisplatin (DDP), bleomycin (BLM), and cyclophosphamide (CTX). Generally, cervical cancer cells were more sensitive to paclitaxel, taxol, and CBP than to other drugs (P<0.05) with inhibition rates of 56.56%, 55.66%, and 46.81%, respectively. Stage Ib1 cervical cancer cells were more sensitive to taxol, paclitaxel, and CBP than to other drugs with inhibition rates of 58.71%, 53.00%, and 49.25%, respectively; stage Ib2 cervical cancer cells were more sensitive to paclitaxel and taxol than to other drugs with inhibition rates of 65.26% and 50.06%. Both moderately and poorly differentiated squamous cell cancer cells were more sensitive to taxol, paclitaxel, and CBP than to other drugs with inhibition rates of 52.01%, 49.21%, and 40.02% for the former, and 60.02%, 61.16%, and 48.75% for the latter. CONCLUSIONS:
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Authors | Yan Xiao, Jun-Dong Li, Hong-Liu Shi, Ji-Hong Liu, Yan-Ling Feng, Meng-Da Li |
Journal | Ai zheng = Aizheng = Chinese journal of cancer
(Ai Zheng)
Vol. 26
Issue 4
Pg. 386-9
(Apr 2007)
China |
PMID | 17430657
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Bleomycin
- Etoposide
- Cyclophosphamide
- Carboplatin
- Paclitaxel
- Cisplatin
- Fluorouracil
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Topics |
- Adult
- Antineoplastic Agents
(pharmacology)
- Bleomycin
(pharmacology)
- Carboplatin
(pharmacology)
- Carcinoma, Squamous Cell
(metabolism, pathology)
- Cell Survival
(drug effects)
- Cells, Cultured
- Cisplatin
(pharmacology)
- Cyclophosphamide
(pharmacology)
- Drug Screening Assays, Antitumor
(methods)
- Etoposide
(pharmacology)
- Female
- Fluorouracil
(pharmacology)
- Humans
- Middle Aged
- Neoplasm Staging
- Paclitaxel
(pharmacology)
- Uterine Cervical Neoplasms
(metabolism, pathology)
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