| Abstract | The levels of HBV replication in the nonreplicative phase are not clear. We conducted this study to evaluate the levels of viral replication during the nonreplicative phase in chronic HBV-infected Korean patients using real-time PCR. A total of 125 patients were classified into three groups: inactive HBsAg carriers, inactive liver cirrhosis patients, and resolved chronic HBV-infected patients with loss of HBsAg. The real-time PCR detected HBV DNA in 112 cases (89.6%). The mean levels of HBV DNA were 3.84, 4.10, and 3.31 log copies/ml in the three groups, respectively (P <0.01). Ninety-five percent of inactive HBsAg carriers showed levels of HBV DNA lower than 6 x 10(4) copies/ml. In conclusion, we showed different levels of HBV DNA exactly in three groups during nonreplicative phases. We suggest that the cutoff level of HBV DNA in inactive HBsAg carriers should be readjusted to a lower level in future studies. |
| Authors | Hyung Joon Yim, Kwan Soo Byun, Yun Jung Chang, Yeon Seok Suh, Jong Eun Yeon, Chang Hong Lee, Jung Ah Kwon, Wangdon Yoo, Soo-Ok Kim, Sun Pyo Hong
(Affiliation: Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.)
|
| Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 52
Issue 9
Pg. 2403-9
(Sep 2007)
ISSN: 0163-2116 United States |
| PMID | 17429737
(Publication Type: Journal Article)
|
| Chemical References |
- DNA, Viral
- Hepatitis B Surface Antigens
|
| Topics |
- Adult
- DNA, Viral
(analysis)
- Female
- Follow-Up Studies
- Hepatitis B Surface Antigens
(immunology)
- Hepatitis B virus
(genetics, immunology, physiology)
- Hepatitis B, Chronic
(epidemiology, pathology, virology)
- Humans
- Incidence
- Korea
(epidemiology)
- Male
- Middle Aged
- Polymerase Chain Reaction
(methods)
- Prognosis
- Severity of Illness Index
- Virus Replication
|
