Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy.

Abstract

Natriuretic peptides (NP) represent a family of structurally homologous but genetically distinct peptide hormones involved in regulation of fluid and electrolyte balance, blood pressure, fat metabolism, cell proliferation, and long bone growth. Recent work suggests a role for natriuretic peptide receptor B (NPR-B) signaling in regulation of cardiac growth by either a direct effect on cardiomyocytes or by modulation of other signaling pathways including the autonomic nervous system. The research links NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in cardiovascular physiology and disease and will evaluate these new findings in the context of the known function of this receptor, with a perspective on how future research might further elucidate NPR-B function.

• Authors: Ines Pagel-Langenickel, Jens Buttgereit, Michael Bader, Thomas H Langenickel
• Journal: Journal of molecular medicine (Berlin, Germany) (J Mol Med (Berl)) Vol. 85 Issue 8 Pg. 797-810 (Aug 2007) ISSN: 0946-2716 [Print] Germany
• PMID: 17429599 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Natriuretic Peptide, C-Type
• Guanylate Cyclase
• Receptors, Atrial Natriuretic Factor
• atrial natriuretic factor receptor B

Topics

• Animals
• Cardiomegaly (metabolism, physiopathology)
• Cardiovascular Physiological Phenomena
• Cardiovascular System (metabolism)
• Guanylate Cyclase (metabolism, physiology)
• Humans
• Models, Biological
• Natriuretic Peptide, C-Type (metabolism, physiology)
• Receptors, Atrial Natriuretic Factor (metabolism, physiology)
• Signal Transduction