Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells.

Abstract

A new isoflavone, named glaziovianin A (1), was isolated from the leaves of Ateleia glazioviana (Legminosae) by means of a cytotoxicity-guided fractionation procedure against HL-60 leukemia cells. The chemical structure of 1 was determined by analysis of its extensive spectroscopic data. Glaziovianin A (1) displayed differential cytotoxicities in the Japanese Foundation for Cancer Research 39 cell line panel assay. The pattern of the differential cytotoxicities of 1 was found to correlate to that shown by TZT-1027, suggesting that 1 inhibited tubulin polymerization as an action mechanism. Although 1 had little influence on microtubule networks in interphase cells, 1-treated cells showed abnormal structures with unaligned chromosomes.

• Authors: Akihito Yokosuka, Mitsue Haraguchi, Takeo Usui, Sayaka Kazami, Hiroyuki Osada, Takao Yamori, Yoshihiro Mimaki
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 17 Issue 11 Pg. 3091-4 (Jun 01 2007) ISSN: 0960-894X [Print] England
• PMID: 17428663 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Isoflavones
• Oligopeptides
• Tubulin
• glaziovianin A
• soblidotin

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Cell Division (drug effects)
• Cell Line, Tumor
• Fabaceae (chemistry)
• HL-60 Cells
• Humans
• Isoflavones (chemistry, isolation & purification, pharmacology)
• Neoplasms (metabolism)
• Oligopeptides (pharmacology)
• Plant Leaves (chemistry)
• Tubulin (drug effects, metabolism)