Development of Kaposi's sarcoma under sirolimus-based immunosuppression and successful treatment with imiquimod.

Kaposi's sarcoma (KS) is a vascular neoplasm typically observed in the immunocompromised patient populations, such as acquired immunodeficiency syndrome or transplant patients. KS can appear simultaneously at multiple sites as red to purple, maculo-papular or nodular cutaneous lesions sometimes showing a visceral extension. Sirolimus, an immunosuppressive agent with potent antitumor activity, has been effective in combating post-transplant KS. However, an aggressive regimen of immunosuppression for therapy of severe acute rejection episodes may abolish the antitumor effects of sirolimus. The following is a description of KS development under immunosuppressive therapy with sirolimus, and the successful treatment of KS lesions utilizing the topical application of imiquimod 5% cream, an immune response modifier.
AuthorsN Babel, N Eibl, C Ulrich, G Bold, A Sefrin, M H Hammer, C Rosenberger, P Reinke
JournalTransplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 10 Issue 1 Pg. 59-62 (Feb 2008) ISSN: 1398-2273 [Print] Denmark
PMID17428275 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Aminoquinolines
  • Antineoplastic Agents
  • Immunosuppressive Agents
  • imiquimod
  • Sirolimus
  • Aged
  • Aminoquinolines (administration & dosage, therapeutic use)
  • Antineoplastic Agents (administration & dosage, therapeutic use)
  • Graft Rejection (drug therapy)
  • Herpesvirus 8, Human (isolation & purification)
  • Humans
  • Immunosuppression
  • Immunosuppressive Agents (adverse effects)
  • Kidney Transplantation (adverse effects)
  • Sarcoma, Kaposi (chemically induced, drug therapy, virology)
  • Sirolimus (adverse effects)

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