[Effect of cerebrokurin and lipin on changes in the rat brain mitochondria in experimental model of hypoxia].

Abstract

The authors carried out the sudy on morphofunctional changes of mitochondria of neurocytes of the brainstem of rats under experimental model of hypoxia and administration of Cerebrokurin and lipin. Cerebrokurin administration to rats which underwent severe chronic hypoxia lead to increase in mitochondria diameter and considerable increase of their area in the unit of volume as well it resulted in renewal of myelin sheaths. Use of Cerebrokurin and lipin in animals which underwent moderate hypoxia lead to probable increase in mitochondria area in the unit of volume in comparison with animals not treated with these agents.

• Authors: T K Znamens'ka, V I Pokhyl'ko, K V Rozova, O M Koval'ova, K O Kostiukova
• Journal: Likars'ka sprava (Lik Sprava) Issue 8 Pg. 84-9 (Dec 2006) ISSN: 1019-5297 [Print] Ukraine
• PMID: 17427432 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amino Acids
• Complex Mixtures
• Organic Chemicals
• Peptides
• lipine

Topics

• Amino Acids (administration & dosage, therapeutic use)
• Animals
• Animals, Newborn
• Brain (drug effects, metabolism, ultrastructure)
• Complex Mixtures
• Disease Models, Animal
• Drug Therapy, Combination
• Energy Metabolism (drug effects)
• Female
• Fetal Hypoxia (pathology)
• Microscopy, Electron, Transmission
• Mitochondria (drug effects, metabolism, ultrastructure)
• Mitochondrial Size (drug effects)
• Organic Chemicals (administration & dosage, therapeutic use)
• Peptides (administration & dosage, therapeutic use)
• Pregnancy
• Rats