Sonodynamic therapy on chemically induced mammary tumor: pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of gallium-porphyrin complex ATX-70.

Abstract

Sonodynamically induced antitumor effect of a gallium porphyrin complex, ATX-70 was evaluated on a chemically induced mammary tumor in Sprague-Dawley rats. The timing of 24 h after the administration of ATX-70 was chosen for ultrasonic exposure, based on pharmacokinetic analysis of ATX-70 concentrations in the tumor, plasma, skin, and muscle. At an ATX-70 dose not less than 2.5 mg/kg and at a free-field ultrasonic intensity not less than 3 W/cm(2), the synergistic effect between ATX-70 administration and ultrasonic exposure on the tumor growth inhibition was significant. These results suggest that ATX-70 is a potential sonosensitizer for sonodynamic treatment of spontaneous mammary tumors.

• Authors: Nagahiko Yumita, Nobuo Okuyama, Kazuaki Sasaki, Shin-Ichiro Umemura
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 60 Issue 6 Pg. 891-7 (Nov 2007) ISSN: 0344-5704 [Print] Germany
• PMID: 17426974 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Photosensitizing Agents
• Porphyrins
• ATX 70
• 9,10-Dimethyl-1,2-benzanthracene

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Antineoplastic Agents (administration & dosage, pharmacokinetics, pharmacology)
• Area Under Curve
• Combined Modality Therapy
• Drug Screening Assays, Antitumor
• Female
• Mammary Neoplasms, Experimental (chemically induced, therapy)
• Photosensitizing Agents (administration & dosage, pharmacokinetics, pharmacology)
• Porphyrins (administration & dosage, pharmacokinetics, pharmacology)
• Rats
• Rats, Sprague-Dawley
• Time Factors
• Tissue Distribution
• Ultrasonic Therapy