Anisaldehyde, a melanogenesis potentiator.

Abstract

Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells.

• Authors: Teruhiko Nitoda, Maria D Fan, Isao Kubo
• Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences (Z Naturforsch C J Biosci) 2007 Jan-Feb Vol. 62 Issue 1-2 Pg. 143-9 ISSN: 0939-5075 [Print] Germany
• PMID: 17425120 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzaldehydes
• Indoles
• Melanins
• melanogen
• 4-anisaldehyde

Topics

• Animals
• Benzaldehydes (pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Humans
• Indoles (pharmacology)
• Kinetics
• Melanins (metabolism)
• Melanoma (pathology, physiopathology)
• Mice