Induction of apoptosis in DLD-1 human colon cancer cells by peridinin isolated from the dinoflagellate, Heterocapsa triquetra.

Abstract

Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0-20 microM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.

• Authors: Tatsuya Sugawara, Kyoko Yamashita, Shota Sakai, Akira Asai, Akihiko Nagao, Tomotaka Shiraishi, Ichiro Imai, Takashi Hirata
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 71 Issue 4 Pg. 1069-72 (Apr 2007) ISSN: 0916-8451 [Print] England
• PMID: 17420600 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• peridinin
• Carotenoids
• Caspase 8
• Caspase 9

Topics

• Animals
• Antineoplastic Agents (isolation & purification, pharmacology)
• Apoptosis (drug effects)
• Carotenoids (isolation & purification, pharmacology)
• Caspase 8 (metabolism)
• Caspase 9 (metabolism)
• Cell Nucleus (drug effects, ultrastructure)
• Cell Survival (drug effects)
• Colonic Neoplasms (drug therapy)
• Dinoflagellida (chemistry)
• Dose-Response Relationship, Drug
• Enzyme Activation (drug effects)
• Enzyme-Linked Immunosorbent Assay
• Humans