Abstract | OBJECTIVE: METHODS AND RESULTS: Incident ischemic stroke and CHD were identified through annual telephone calls and hospital and death certificate surveillance. Five hundred and twenty-five validated ischemic stroke and 1654 CHD events were identified. Allele frequencies for all PSEL and PSGL-1 polymorphisms were markedly different between whites and African Americans; therefore, all analyses were performed race-specific. Independent analyses showed the PSEL 290NN genotype to be a significant predictor of CHD in whites (HRR 1.30, 95%CI 1.00-1.70, P=0.05). PSGL-1 genotypes carrying the 62I allele were significantly protective for incident CHD (HRR 0.53, 95%CI 0.31-0.92, P=0.02) and ischemic stroke (HRR 0.73, 95%CI 0.55-0.97, P=0.03) in African Americans. Haplotype analyses showed the PSEL NNVP haplotype to be a significant predictor of incident CHD in whites (HRR 2.09, 95%CI 1.23-3.55, P=0.006). No significant haplotype findings were observed in African Americans. CONCLUSIONS: PSEL S290N, in single polymorphism analysis and in the haplotypic background with T715P, was associated with increased risk of incident CHD in whites. The PSGL-1 M62I polymorphism was associated with decreased risk of both incident CHD and stroke in African Americans. These findings illustrate the complex relationship between genetic variation and disease in different racial groups.
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Authors | Kelly A Volcik, Christie M Ballantyne, Josef Coresh, Aaron R Folsom, Eric Boerwinkle |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 195
Issue 1
Pg. e76-82
(Nov 2007)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 17420019
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Membrane Glycoproteins
- P-Selectin
- P-selectin ligand protein
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Topics |
- Aged
- Atherosclerosis
(diagnosis, genetics)
- Cell Adhesion
- Coronary Artery Disease
(diagnosis, ethnology, genetics)
- Genotype
- Haplotypes
- Humans
- Incidence
- Ischemia
(pathology)
- Membrane Glycoproteins
(genetics, physiology)
- Middle Aged
- P-Selectin
(genetics, physiology)
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide
- Risk
- Stroke
(diagnosis, ethnology, genetics)
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