Abstract | BACKGROUND: OBJECTIVE: METHODS: In this uncontrolled pilot study, 15 patients with 20 attacks were treated with Icatibant. The attacks were analyzed by using a standardized and validated visual analog scale measurement and compared with historical data of untreated attacks. Plasma bradykinin concentration was measured before and 4 hours after intravenous Icatibant treatment. RESULTS: Symptom intensity decreased within 4 hours after administration of Icatibant; the median time to onset of symptom relief was 1.50, 1.42, and 1.13 hours in the intravenous groups and 0.58 and 0.45 hours in the subcutaneous groups, respectively. The median difference in the 10-cm visual analog scale 4 hours after start of treatment was 4.11 cm (95% CI, 1.72-6.07). Compared with untreated attacks, Icatibant treatment reduced the mean (SD) time to onset of symptom relief by 97% from 42 +/- 14 to 1.16 +/- 0.95 hours (all groups combined). Median bradykinin concentration was 7-fold above the norm during acute attacks at 48.5 pmol/L and decreased to 18.0 pmol/L 4 hours after Icatibant infusion or injection. CONCLUSION: CLINICAL IMPLICATIONS:
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Authors | Konrad Bork, Jorge Frank, Boris Grundt, Peter Schlattmann, Juerg Nussberger, Wolfhart Kreuz |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 119
Issue 6
Pg. 1497-503
(Jun 2007)
ISSN: 0091-6749 [Print] United States |
PMID | 17418383
(Publication Type: Clinical Trial, Phase I, Journal Article)
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Chemical References |
- Bradykinin B2 Receptor Antagonists
- icatibant
- Bradykinin
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Topics |
- Acute Disease
- Adult
- Angioedema
(drug therapy, genetics, metabolism)
- Bradykinin
(adverse effects, analogs & derivatives, therapeutic use)
- Bradykinin B2 Receptor Antagonists
- Female
- Genetic Diseases, Inborn
(drug therapy, metabolism)
- Humans
- Male
- Middle Aged
- Pilot Projects
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