Inhibition of monosodium urate monohydrate-mediated hemolysis by vitamin E.

Abstract

Microcrystals of monosodium urate monohydrate (MSUM) induce cytolysis and hemolysis in erythrocytes. In this report, we studied the effect of vitamin E on MSUM-mediated hemolysis in human erythrocytes. Vitamin E significantly inhibited hemolysis induced by MSUM. The hydroxyl group in the chromanol ring of vitamin E is dispensable for protecting erythrocytes against hemolysis induced by MSUM, indicating that the inhibitory effect of vitamin E is not due to its antioxidant properties. However, both the chromanol ring and the isoprenoid side chain are important for vitamin E to suppress MSUM-induced hemolysis. Our current study suggests that vitamin E inhibits hemolysis induced by MSUM as a membrane stabilizer.

• Authors: Qiong Xie, Shude Li, Weiyang Feng, Yongzhi Li, Yuanliang Wu, Wei Hu, Youguang Huang
• Journal: Acta biochimica et biophysica Sinica (Acta Biochim Biophys Sin (Shanghai)) Vol. 39 Issue 4 Pg. 273-7 (Apr 2007) ISSN: 1672-9145 [Print] China
• PMID: 17417682 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Isotonic Solutions
• Vitamin E
• Uric Acid

Topics

• Antioxidants (pharmacology)
• Crystallization
• Dose-Response Relationship, Drug
• Erythrocyte Membrane (drug effects, metabolism)
• Hemolysis (drug effects, physiology)
• Humans
• Isotonic Solutions (chemistry)
• Kinetics
• Uric Acid (antagonists & inhibitors, metabolism, pharmacology)
• Vitamin E (pharmacology)