Abstract | BACKGROUND: OBJECTIVE: We investigated the genotypic and allelic frequencies of MTHFD1 1958G>A (R653Q) and MTR 2756A>G (D919G) gene polymorphisms in a group of bipolar (n=200) and schizophrenic patients (n=200), as well as in controls (n=300). METHODS: The distributon of genotypes in all groups was tested for deviation from Hardy-Weinberg equilibrium (HWE). The Pearson's chi-square (chi) test and Fisher's exact test were applied to assess differences in the genotypic and allelic (respectively) distribution between groups of patients and controls. MAIN RESULTS: We found that MTHFD1 1958AA or 1958AG genotypes constitute risk factors for development of bipolar disorder type I (BDI) or schizophrenia with odds ratios (OR)=1.743 (95% CI=1.211-2.508; P=0.0027; P (corr)=0.0054) and 2.667 (95% CI=1.845-3.854; P=0.0001; P (corr)=0.0002), respectively. In the same groups, the MTR 2756GG or 2756AG genotypes also constitute significant risk factors in occurrence of BDI and schizophrenia with OR=1.621 (95% CI=1.130-2.326; P=0.0086; P (corr)=0.0172) and 1.556 (95% CI=1.085-2.232; P=0.0160; P (corr)=0.032), respectively. Gender classification of patients indicated significant association only of MTHFD1 1958A allele with BDI and schizophrenia in the male patients OR=1.838 (95% CI=1.114-3.031; P=0.0166; P (corr)=0.0332) and OR=3.964 (95% CI=2.358-6.663; P=0.0001 P (corr)=0.0002), respectively. CONCLUSION: Since MTHFD and MTR genes are located in 14q24 and 1q43 loci, our findings support the significance of chromosomes 14q and 1q in etiopathogenesis of bipolar disorder and schizophrenia.
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Authors | Bartosz Kempisty, Jacek Sikora, Margarita Lianeri, Aleksandra Szczepankiewicz, Piotr Czerski, Joanna Hauser, Paweł Piotr Jagodzinski |
Journal | Psychiatric genetics
(Psychiatr Genet)
Vol. 17
Issue 3
Pg. 177-81
(Jun 2007)
ISSN: 0955-8829 [Print] England |
PMID | 17417062
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Guanine
- Methylenetetrahydrofolate Dehydrogenase (NADP)
- Adenine
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Topics |
- Adenine
- Bipolar Disorder
(enzymology, genetics)
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 4
- Demography
- Female
- Gene Frequency
- Guanine
- Humans
- Male
- Methylenetetrahydrofolate Dehydrogenase (NADP)
(genetics)
- Polymorphism, Single Nucleotide
- Reference Values
- Schizophrenia
(enzymology, genetics)
- White People
(genetics)
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