Abstract | PURPOSE: PATIENTS AND METHODS: Definitive radiotherapy was performed in 41 patients with squamous cell anal carcinoma. The majority (51.2%) of them were in T3 stage. Positive inguinal lymph nodes were found in 10 (24.4%) patients. Initially, all patients received external beam radiotherapy with pelvic fields, followed, after a 2-week gap in some patients or in continuity, by local external beam or brachytherapy boost. The total tumor dose ranged from 55-75 Gy. RESULTS: Acute complications were noticed in 32 (78%) patients with moist skin perineal desquamation being the most frequent (63.5%). On the first follow-up examination (2 months after the end of radiotherapy) 65.9% of the patients were in complete remission (CR), 31.7% in partial remission (PR), while in one (2.4%) patient locoregional disease progression (PD) was registered. With a mean follow- up time of 38.4 months (range 12-90 months) 75.6% of the patients were disease-free, while local or distant disease progression was diagnosed in 24.4% of them. Local disease control was achieved in 82.9% of the patients. The 5-year overall survival was 76.59%. Late sequelae, which were of low grade (1 and 2), were registered in 22 (53.7%) patients. CONCLUSION:
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Authors | S Stojanović, Lj Radosević Jelić |
Journal | Journal of B.U.ON. : official journal of the Balkan Union of Oncology
(J BUON)
2004 Jul-Sep
Vol. 9
Issue 3
Pg. 269-73
ISSN: 1107-0625 [Print] Cyprus |
PMID | 17415825
(Publication Type: Journal Article)
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