The anti-cancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells.

Abstract	The chemokine receptor CXCR4 plays an important role in tumor growth, angiogenesis and metastasis. Our previous studies showed that Nordy, a synthetic chiral compound of nordihydroguaiaretic acid, inhibited the growth and angiogenesis of various malignant tumors. In this study we examined the capacity of Nordy to regulate CXCR4-mediated production of angiogenic factors by human glioblastoma cells. We found that Nordy potently inhibited CXCR4 ligand SDF-1-induced production of IL-8 and vascular endothelial cell growth factor, two important angiogenic factors implicated in the progression of malignant tumors. Further study revealed that the effect of Nordy was attributable to its down-regulation of the expression of functional CXCR4 in glioblastoma cells. These results suggest that the anti-cancer activity of Nordy is due, at least in part, to its suppression of the chemokine receptor CXCR4 thus reducing the production of angiogenic factors by tumor cells.
Authors	Yi-fang Ping, Xiao-hong Yao, Jian-hong Chen, Hong Liu, Dai-lun Chen, Xiang-dong Zhou, Ji Ming Wang, Xiu-wu Bian
Journal	Journal of neuro-oncology (J Neurooncol) Vol. 84 Issue 1 Pg. 21-9 (Aug 2007) ISSN: 0167-594X [Print] United States
PMID	17415525 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Angiogenic Proteins Antineoplastic Agents Interleukin-8 Lignans Lipoxygenase Inhibitors RNA, Messenger Receptors, CXCR4 Vascular Endothelial Growth Factor A nordy Masoprocol
Topics	Analysis of Variance Angiogenic Proteins (metabolism) Animals Antineoplastic Agents (pharmacology) Brain Neoplasms (drug therapy, metabolism) Cell Line, Tumor Down-Regulation Gene Expression Regulation, Neoplastic (drug effects) Glioma (drug therapy, metabolism) Humans Interleukin-8 (genetics, metabolism) Lignans (pharmacology) Lipoxygenase Inhibitors (pharmacology) Masoprocol (chemistry, pharmacology) Mice Mice, Inbred BALB C Mice, Nude RNA, Messenger (analysis) Receptors, CXCR4 (drug effects, metabolism) Vascular Endothelial Growth Factor A (drug effects, genetics, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!