Gastroprotective properties of 11-deoxymisoprostol (prostaglandin E1 analog) and its effect on the level of sialic acids in gastric tissue of rats with peptic ulcer.

Abstract

11-Deoxymisoprostol (prostaglandin E1 analog) exhibited a pronounced gastroprotective effect on various models of experimental ulcers induced by nonsteroid antiinflammatory drugs. A relationship between high resistance of the gastroduodenal mucosa under the effect of 11-deoxymisoprostol and changes in the level of sialic acid was detected.

• Authors: N Zh Baschenko, T A Sapozhnikova, S F Gabdrakhmanova, N S Makara, R Yu Khisamutdinova, F S Zarudii, N A Ivanova, V S Nazarov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 142 Issue 4 Pg. 467-9 (Oct 2006) ISSN: 0007-4888 [Print] United States
• PMID: 17415439 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol
• Anti-Inflammatory Agents, Non-Steroidal
• Anti-Ulcer Agents
• Sialic Acids
• Misoprostol

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (toxicity)
• Anti-Ulcer Agents (pharmacology)
• Gastric Mucosa (drug effects, metabolism)
• Male
• Misoprostol (analogs & derivatives, pharmacology)
• Peptic Ulcer (chemically induced, drug therapy, metabolism)
• Rats
• Rats, Wistar
• Sialic Acids (metabolism)