| Abstract | N-Docosahexaenoyl dopamine exhibited antioxidant activity in the test with a stable oxygen radical galvinoxyl. This compound produced a dose-dependent protective effect on cultured granular cells from rat cerebellum under conditions of oxidative stress. N-Docosahexaenoyl dopamine decelerated the development of symptoms of Parkinson's disease in mice receiving neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. |
| Authors | M Yu Bobrov, A A Lyzhin, E L Andrianova, N M Gretskaya, G N Zinchenko, L E Frumkina, L G Khaspekov, V V Bezuglov
(Affiliation: Laboratory of Oxylipins, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.)
|
| Journal | Bulletin of experimental biology and medicine
(Bull Exp Biol Med)
Vol. 142
Issue 4
Pg. 425-7
(Oct 2006)
ISSN: 0007-4888 United States |
| PMID | 17415428
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antioxidants
- N-docosahexaenoyl dopamine
- Neuroprotective Agents
- Dopamine
|
| Topics |
- Animals
- Antioxidants
(pharmacology)
- Cells, Cultured
- Cerebellum
(cytology, drug effects, physiology)
- Dopamine
(analogs & derivatives, pharmacology)
- Dose-Response Relationship, Drug
- Neurons
(drug effects, physiology)
- Neuroprotective Agents
(pharmacology)
- Oxidative Stress
(drug effects)
- Parkinsonian Disorders
(physiopathology)
- Rats
|
