Small number of HTLV-1-positive cells frequently remains during complete remission after allogeneic hematopoietic stem cell transplantation that are heterogeneous in origin among cases with adult T-cell leukemia/lymphoma.
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| Abstract |
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can provide long-term remission for patients with adult T-cell leukemia/lymphoma (ATLL) caused by human retrovirus, human T-lymphocyte virus (HTLV-1). To understand how HTLV-1-positive cells including ATLL cells were suppressed by allo-HSCT, we examined HTLV-1 provirus load and residual ATLL cells in peripheral blood of transplant recipients using PCR-based tests. We found that the copy number of HTLV-1 genome, called provirus, became very small in number after allo-HSCT; however, in most cases, provirus did not disappear even among long-term survivors. Tumor-specific PCR tests demonstrated that most of HTLV-1-positive cells that remained long after transplantation were not primary ATLL cells but donor-derived HTLV-1-positive cells. We also found a case having very low amount of residual disease in peripheral blood even long after transplantation. There was only one recipient in whom we failed to show the presence of HTLV-1 genome and antibody against HTLV-1 even with an extensive search, which strongly suggested the elimination of HTLV-1 after allo-HSCT. These results demonstrated that after allo-HSCT the small amount of residual HTLV-1-positive cells were heterogeneous in origin and that long-term disease control for ATLL could be obtained without the complete elimination of HTLV-1.
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| Authors | R Yamasaki, Y Miyazaki, Y Moriuchi, C Tsutsumi, T Fukushima, S Yoshida, J Taguchi, Y Inoue, E Matsuo, Y Imaizumi, D Imanishi, T Fujimoto, H Tsushima, S Honda, T Hata, K Tsukasaki, M Tomonaga |
| Journal | Leukemia (Leukemia) Vol. 21 Issue 6 Pg. 1212-7 (Jun 2007) ISSN: 0887-6924 [Print] England |
| PMID | 17410191 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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