Complete response of deep neutrophilic dermatosis associated with myelodysplastic syndrome to 5-azacytidine.

Cutaneous manifestations of myelodysplastic syndromes (MDS) may predict disease progression and a poorer prognosis. We describe a patient in whom a deep neutrophilic dermatosis preceded evolution of disease from refractory anaemia to RAEB (refractory anaemia with excess blasts) and resolved completely on treating the disease with 5-azacytidine. The dermatological response was accompanied by complete bone marrow remission and trilineage haematological improvement. We suggest that 5-azacytidine should be considered in the treatment of immune mediated cutaneous manifestations of MDS.
AuthorsK Raj, A Ho, J D Creamer, A W P du Vivier, J R Salisbury, G J Mufti
JournalThe British journal of dermatology (Br J Dermatol) Vol. 156 Issue 5 Pg. 1039-41 (May 2007) ISSN: 0007-0963 [Print] England
PMID17408390 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antimetabolites, Antineoplastic
  • Azacitidine
  • Aged
  • Anemia, Refractory, with Excess of Blasts (complications)
  • Antimetabolites, Antineoplastic (therapeutic use)
  • Azacitidine (therapeutic use)
  • Head
  • Humans
  • Male
  • Neck
  • Remission Induction
  • Shoulder
  • Skin Diseases (drug therapy, etiology)

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