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Folic acid-conjugated protein cages of a plant virus: a novel delivery platform for doxorubicin.

Abstract
The protein cage of a plant virus may provide a template for monodispersed nanosized systems for drug delivery. Using the Hibiscus chlorotic ringspot virus (HCRSV) as a model plant virus, we have prepared nanosized protein cages (30 nm) capable of encapsulating the anticancer drug, doxorubicin. The technique utilized the simultaneous encapsulation of a polyprotic acid of mw 200 kDa to produce an encapsulation efficiency for doxorubicin of about 7.5%. Folic acid was conjugated onto the capsids to impart cancer-targeting capability. The resultant nanosized systems improved the uptake and cytotoxicity of doxorubicin in the ovarian cancer cells, OVCAR-3, with statistical significance. Plant virus capsids may therefore provide viable templates for targeted drug delivery in cancer chemotherapy.
AuthorsYupeng Ren, Sek Man Wong, Lee-Yong Lim
JournalBioconjugate chemistry (Bioconjug Chem) 2007 May-Jun Vol. 18 Issue 3 Pg. 836-43 ISSN: 1043-1802 [Print] United States
PMID17407258 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibiotics, Antineoplastic
  • Capsid Proteins
  • Doxorubicin
  • Folic Acid
Topics
  • Antibiotics, Antineoplastic (administration & dosage, chemistry)
  • Biological Transport
  • Capsid Proteins (chemistry)
  • Cell Line, Tumor
  • Doxorubicin (administration & dosage, chemistry, metabolism)
  • Drug Delivery Systems
  • Folic Acid (chemistry)
  • Humans
  • Nanoparticles (administration & dosage, chemistry)
  • Plant Viruses (chemistry)

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