Abstract |
The protein cage of a plant virus may provide a template for monodispersed nanosized systems for drug delivery. Using the Hibiscus chlorotic ringspot virus (HCRSV) as a model plant virus, we have prepared nanosized protein cages (30 nm) capable of encapsulating the anticancer drug, doxorubicin. The technique utilized the simultaneous encapsulation of a polyprotic acid of mw 200 kDa to produce an encapsulation efficiency for doxorubicin of about 7.5%. Folic acid was conjugated onto the capsids to impart cancer-targeting capability. The resultant nanosized systems improved the uptake and cytotoxicity of doxorubicin in the ovarian cancer cells, OVCAR-3, with statistical significance. Plant virus capsids may therefore provide viable templates for targeted drug delivery in cancer chemotherapy.
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Authors | Yupeng Ren, Sek Man Wong, Lee-Yong Lim |
Journal | Bioconjugate chemistry
(Bioconjug Chem)
2007 May-Jun
Vol. 18
Issue 3
Pg. 836-43
ISSN: 1043-1802 [Print] United States |
PMID | 17407258
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibiotics, Antineoplastic
- Capsid Proteins
- Doxorubicin
- Folic Acid
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Topics |
- Antibiotics, Antineoplastic
(administration & dosage, chemistry)
- Biological Transport
- Capsid Proteins
(chemistry)
- Cell Line, Tumor
- Doxorubicin
(administration & dosage, chemistry, metabolism)
- Drug Delivery Systems
- Folic Acid
(chemistry)
- Humans
- Nanoparticles
(administration & dosage, chemistry)
- Plant Viruses
(chemistry)
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