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Mini-dose of thalidomide for treatment of primary myelofibrosis. Report of a case with complete reversal of bone marrow fibrosis and splenomegaly.

AbstractWe report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly and bone narrow fibrosis after 30 months of the treatment.
AuthorsAlain Berrebi, Edit Feldberg, Irena Spivak, Lev Shvidel (Affiliation: Hematology Institute, Kaplan Medical Center, Rehovot, Israel 76100. alain_b at clalit.org.il)
JournalHaematologica (Haematologica) Vol. 92 Issue 2 Pg. e15-6 (Feb 2007) ISSN: 1592-8721 Italy
PMID17405746 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Angiogenesis Inhibitors
  • Vitamin B Complex
  • Thalidomide
  • Prednisone
  • Folic Acid
  • Fluoxymesterone
Topics
  • Aged, 80 and over
  • Angiogenesis Inhibitors (administration & dosage, therapeutic use)
  • Blood Transfusion
  • Bone Marrow (pathology)
  • Combined Modality Therapy
  • Drug Therapy, Combination
  • Fluoxymesterone (administration & dosage, therapeutic use)
  • Folic Acid (administration & dosage, therapeutic use)
  • Humans
  • Male
  • Myelofibrosis (complications, drug therapy, pathology, therapy)
  • Prednisone (administration & dosage, therapeutic use)
  • Remission Induction
  • Splenomegaly (etiology)
  • Thalidomide (administration & dosage, therapeutic use)
  • Vitamin B Complex (administration & dosage, therapeutic use)