Abstract |
The purpose of this study was to compare the diagnostic efficacy of double-dose 1.0-M gadobutrol with that of standard-dose 0.5-M gadopentetate dimeglumine for revealing small hypervascular hepatocellular carcinomas (HCCs). Twenty-three patients with 37 HCCs (mean size: 1.2 cm) that were diagnosed by histology (n = 13) or imaging findings (n = 10) underwent two separate 3D dynamic MRIs with 0.2 mmol/kg of gadobutrol and 0.1 mmol/kg of gadopentetate dimeglumine. Three observers interpreted both MRIs in terms of lesion detection using the alternative-free response receiver operating characteristic method and lesion-to-liver contrast using matched pairs analysis. The two MRIs were also compared quantitatively by measuring the signal-to-noise ratio (SNR) of the liver and lesion as well as the lesion-liver contrast-to-noise ratio (CNR). The SNR of the liver and lesion and lesion-liver CNR with gadobutrol were better than those with gadopentetate dimeglumine (p < 0.01). However, in terms of the diagnostic accuracy (mean Az for gadobutrol: 0.878, and mean Az for gadopentate dimeglumine: 0.873), the sensitivity (92.8%), positive predictive value (92.8% vs. 93.7%) and lesion-liver contrast, the two dynamic MRIs were equivalent. Gadobutrol showed a superior degree of enhancement for hypervascular HCC than did gadopentetate dimeglumine, but the diagnostic capabilities of the two agents for revealing HCCs were equivalent.
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Authors | Young Kon Kim, Young Hwan Lee, Chong Soo Kim, Young Min Han, Seung Bae Hwang |
Journal | European radiology
(Eur Radiol)
Vol. 18
Issue 1
Pg. 70-7
(Jan 2008)
ISSN: 0938-7994 [Print] Germany |
PMID | 17404740
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Contrast Media
- Organometallic Compounds
- gadobutrol
- Gadolinium DTPA
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Topics |
- Adult
- Aged
- Carcinoma, Hepatocellular
(diagnosis)
- Contrast Media
(administration & dosage)
- Female
- Gadolinium DTPA
(administration & dosage)
- Humans
- Image Interpretation, Computer-Assisted
- Injections, Intravenous
- Liver Neoplasms
(diagnosis)
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Organometallic Compounds
(administration & dosage)
- Predictive Value of Tests
- ROC Curve
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