Immunoglobulin treatment for primary antibody deficiencies: advantages of the subcutaneous route.

Adults and children with primary antibody deficiencies are prone to bacterial infections affecting the respiratory tract and gastrointestinal canal. To prevent or alleviate infections, replacement therapy with IgG is needed, usually on a lifelong basis. The IgG can be administered intramuscularly, intravenously, or subcutaneously. Subcutaneous IgG (SCIG) therapy, using small portable pumps for once-per-week self infusions, has shown many advantages compared with the two other routes of administration. This review highlights findings from international studies and demonstrates that: (i) SCIG therapy is safe, with very few adverse effects; (ii) the therapy can be used for patients with previous adverse effects to intravenous administration of IgG; (iii) the therapy leads to high serum IgG levels and good protection against infections; (iv) the therapy facilitates home therapy, as the infusion technique is easy for children, adults and elderly people to learn and there is no need for venous access; (v) SCIG home therapy leads to significantly improved life situations for the patients; (vi) the SCIG home therapy regimen in particular reduces the costs of treatment.
AuthorsAnn Gardulf
JournalBioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy (BioDrugs) Vol. 21 Issue 2 Pg. 105-16 ( 2007) ISSN: 1173-8804 [Print] New Zealand
PMID17402794 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Immunoglobulin G
  • Bacterial Infections (prevention & control)
  • Health Care Costs
  • Home Infusion Therapy
  • Humans
  • Immunoglobulin G (administration & dosage, adverse effects, blood)
  • Immunologic Deficiency Syndromes (therapy)
  • Injections, Subcutaneous
  • Quality of Life

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: