| Abstract | ImuVert, a biologic response modifier, and interleukin 1 (IL 1) have been shown to protect the young rat from alopecia induced by cytarabine (ARA-C). In the present study the inhibition by ARA-C of DNA synthesis in hair follicles (HFs) and the protective effect of ImuVert and IL 1 were investigated in vivo and in vitro. Both ImuVert and IL 1 were equally effective in protecting rats from ARA-C-induced alopecia. DNA synthesis in HFs isolated from ARA-C-treated animals was 10-20% of untreated controls. Follicles isolated from animals given either ImuVert or IL 1 before ARA-C exhibited normal DNA synthesis. In vitro, the incubation of normal rat HF with ARA-C resulted in 80% inhibition of [3H]-thymidine uptake. Preincubation of the follicles for 1 hr with IL 1 before the addition of ARA-C completely blocked the inhibition. Preincubation with imuVert, however, was less effective in blocking the inhibition from ARA-C. |
| Authors | J J Jimenez, M E Sawaya, A A Yunis
(Affiliation: Department of Medicine, University of Miami School of Medicine, Florida 33101.)
|
| Journal | The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
(FASEB J)
Vol. 6
Issue 3
Pg. 911-3
(Feb 1 1992)
ISSN: 0892-6638 UNITED STATES |
| PMID | 1740239
(Publication Type: In Vitro, Journal Article)
|
| Chemical References |
- Antineoplastic Agents
- Biological Products
- Immunologic Factors
- ImuVert
- Interleukin-1
- Cytarabine
|
| Topics |
- Alopecia
(chemically induced, drug therapy)
- Animals
- Antineoplastic Agents
(pharmacology)
- Biological Products
- Cytarabine
(toxicity)
- DNA Replication
(drug effects)
- Dose-Response Relationship, Drug
- Drug Antagonism
- Hair
(drug effects)
- Immunologic Factors
(pharmacology)
- Interleukin-1
(pharmacology)
- Rats
- Rats, Inbred Strains
|
