Assessment of antioxidant effect of 2,5-dihydroxybenzoic acid and vitamin a in brains of rats with induced hyperoxia.

Abstract

The aim of this study was to evaluate the effect of 2,5-dihydroxybenzoic acid, a salicylate derived from Acetyl salicylic acid (ASA) and vitamin A (vit A) on Na(+), K(+) ATPase enzyme and GSH levels in brain of rats exposed to hyperoxia (Hyp) as oxidant protocol. Rats were treated as follow: group I (control), group II (Hyp), group III (Hyp, ASA), group IV (vit A), group V (Hyp, vit A), group VI (Hyp, vit A, ASA). Vit A was given 5 days before and during Hyp, aspirin at the end of Hyp. Na(+),K(+) ATPase and total ATPase activity was significantly increased in group V. Levels of GSH showed a significant increase in group III, besides, levels of 2,5-dihydroxybenzoic acid as salicylate in plasma were significantly increased in group II. These results elucidate differences in the biochemical response of animal towards intake of various types of antioxidant substances, with increased GSH and salicylate in hyperoxia.

• Authors: David Calderón Guzmán, Francisca Trujillo Jiménez, Ernestina Hernández García, Hugo Juárez Olguín
• Journal: Neurochemical research (Neurochem Res) Vol. 32 Issue 6 Pg. 1036-40 (Jun 2007) ISSN: 0364-3190 [Print] United States
• PMID: 17401673 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Free Radicals
• Gentisates
• Salicylates
• Vitamin A
• Sodium-Potassium-Exchanging ATPase
• Glutathione
• 2,5-dihydroxybenzoic acid

Topics

• Animals
• Antioxidants
• Brain Chemistry (drug effects)
• Female
• Free Radicals (metabolism)
• Gentisates (pharmacology)
• Glutathione (metabolism)
• Hyperoxia (drug therapy, metabolism)
• Oxidative Stress (drug effects, physiology)
• Rats
• Rats, Sprague-Dawley
• Salicylates (blood)
• Sodium-Potassium-Exchanging ATPase (metabolism)
• Vitamin A (pharmacology)