| Abstract | Renal function, evaluated as glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), was investigated in 187 pediatric patients who underwent allogeneic (n=169) or autologous bone marrow transplantation (BMT). Allogeneic BMT patients were divided into three groups: hematological malignancies, aplastic anemia and non-malignant diseases, whereas autologous patients constituted a fourth group. A total of 64% received total body irradiation (TBI) as conditioning therapy, and 50 healthy children served as controls. GFR and ERPF were normal before transplantation. After 1 year, both GFR and ERPF were significantly reduced. GFR had recovered slightly after 3 years and remained stable thereafter. Recovery in ERPF was not apparent. Renal impairment was found in 41% of patients at 1 year, in 31% at 3 years and in 11% 7 years after BMT. Patients with hematological malignancies had lower GFRs than patients with non-malignant diseases at all time points. The most important risk factor as regards chronic renal impairment was TBI. Type of donor, cyclophosphamide (CY), or acute graft-versus-host disease (GVHD) did not seem to contribute to the development of chronic renal impairment. We suggest that tests of renal function should be included in long-term followup after BMT. |
| Authors | M H Grönroos, P Bolme, J Winiarski, U B Berg
(Affiliation: Department of Pediatrics, Turku University Central Hospital, Turku, Finland.)
|
| Journal | Bone marrow transplantation
(Bone Marrow Transplant)
Vol. 39
Issue 11
Pg. 717-23
(Jun 2007)
ISSN: 0268-3369 England |
| PMID | 17401393
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Topics |
- Adolescent
- Anemia, Aplastic
(therapy)
- Bone Marrow Transplantation
(adverse effects)
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Glomerular Filtration Rate
- Graft vs Host Disease
(complications)
- Hematologic Neoplasms
(therapy)
- Humans
- Infant
- Kidney
(physiology)
- Kidney Failure, Chronic
(etiology)
- Kidney Function Tests
- Male
- Renal Circulation
- Retrospective Studies
- Transplantation Conditioning
(adverse effects)
- Transplantation, Autologous
- Transplantation, Homologous
- Whole-Body Irradiation
(adverse effects)
|
