| Abstract | OBJECTIVE: The present study aimed at verifying the safety and efficacy of rifampicin in ameliorating pruritus in cholestatic children. METHODS: Twenty-three Egyptian children (14 boys and 9 girls), suffering from intractable pruritus of cholestasis, were included. Rifampicin was started at a dose of 10 mg/Kg/day in two divided doses and increased gradually to a maximum of 20 mg/Kg/day if there was no response. Liver function tests were followed up weekly. RESULTS: Seventeen patients (74%) showed improvement of pruritus with rifampicin. None of the patients showed any deterioration in liver functions. CONCLUSION: Rifampicin in a dose of 10-20 mg/Kg/day is safe and effective in ameliorating uncontrollable pruritus in children with persistent cholestasis. |
| Authors | Hanaa El-Karaksy, Samah Mansour, Rokaya El-Sayed, Mona El-Raziky, Nehal El-Koofy, Gamal Taha
(Affiliation: Cairo University, Cairo, Egypt. hanaakaraksy at yahoo.com)
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| Journal | Indian journal of pediatrics
(Indian J Pediatr)
Vol. 74
Issue 3
Pg. 279-81
(Mar 2007)
ISSN: 0973-1679 India |
| PMID | 17401268
(Publication Type: Journal Article)
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| Chemical References |
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| Topics |
- Adolescent
- Child
- Child, Preschool
- Cholestasis
(complications)
- Female
- Humans
- Infant
- Male
- Pruritus
(drug therapy, etiology)
- Rifampin
(adverse effects, therapeutic use)
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