The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium.

Abstract

Four compounds were isolated from Enicosanthum membranifolium. The structures of the compounds were confirmed by spectroscopic data. Their structures were determined as N-trans-feruloyltyramine, R-(-)-mellein, clerodermic acid, and salicifoline chloride as a quaternary alkaloid compound. The structures of R-(-)-mellein and salicifoline chloride were confirmed by using X-ray diffraction. Clerodermic acid was shown to induce potent apoptosis against human leukemia HL60 cells.

• Authors: Mai Efdi, Tomohiro Itoh, Yukihiro Akao, Yoshinori Nozawa, Mamoru Koketsu, Hideharu Ishihara
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 15 Issue 11 Pg. 3667-71 (Jun 01 2007) ISSN: 0968-0896 [Print] England
• PMID: 17400462 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Antineoplastic Agents
• Coumaric Acids
• Isocoumarins
• Lactones
• Naphthalenes
• Ochratoxins
• clerodermic acid
• feruloyltyramine
• salicifoline
• Tyramine
• ochracin

Topics

• Alkaloids (chemistry, isolation & purification, pharmacology)
• Annonaceae (metabolism)
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Cell Proliferation (drug effects)
• Coumaric Acids (chemistry, isolation & purification, pharmacology)
• Humans
• Isocoumarins (chemistry, isolation & purification, pharmacology)
• Lactones (chemistry, isolation & purification, pharmacology)
• Naphthalenes (chemistry, isolation & purification, pharmacology)
• Ochratoxins (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured
• Tyramine (analogs & derivatives, chemistry, isolation & purification, pharmacology)