| Abstract | During the past six years an increasing number of liver-cell adenomas in women were diagnosed, and we undertook a study of possible etiologic factors, including use of oral contraceptives, in 42 women. There was a significant difference between cases and matched controls in mean months of oral-contraceptive use: 73.4 as compared to 36.2 (P less than 0.001). The women with adenomas took mestranol-containing pills much more commonly than the controls (P less than 0.0001). Hemorrhage into the tumor was often associated with the onset of menstruation in women taking oral contraceptives. Long-term use of oral contraceptives, especially those containing a high total dose of steroids or mestranol as the synthetic estrogen, should be balanced against risks of side effects of the drugs. |
| Authors | H A Edmondson, B Henderson, B Benton |
| Journal | The New England journal of medicine
(N Engl J Med)
Vol. 294
Issue 9
Pg. 470-2
(Feb 26 1976)
ISSN: 0028-4793 UNITED STATES |
| PMID | 173996
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
- Contraceptives, Oral
- Ethinyl Estradiol
- Mestranol
|
| Topics |
- Adult
- Carcinoma, Hepatocellular
(chemically induced, pathology)
- Contraceptives, Oral
(adverse effects)
- Ethinyl Estradiol
(adverse effects)
- Female
- Humans
- Liver
(pathology)
- Liver Neoplasms
(chemically induced, pathology)
- Mestranol
(adverse effects)
- Middle Aged
- Risk
- Time Factors
|
